Table 2.
MAGUKs, their functions and involvement in diseases
| Name | Functions | Disease | Ref. |
|---|---|---|---|
| DLG | Maintenance of cell polarity, cell proliferation, migration and adhesion, cell division, synapse formation. |
Breast, cervical and clolon cancer, kidney disease and renal failure, schizophrenia, etc. | 23, 33, 59-61 |
| CASK | Maintenance of cell polarity, progenitor population, synapse formation, cell migration. |
Kidney disease and renal failure, nystagmus, Ohtahara syndrome and cerebellar hypoplasia, Pontocerebellar hypoplasia, etc. |
12, 23, 61 |
| MPP1 | Maintenance of cell polarity, invasion, cell division. | Paroxysmal nocturnal haemoglobinuria, idiopathic ataxia, etc. | 62, 63 |
| MPP5 | Maintenance of cell polarity, cell proliferation. | Prostate cancer | 64 |
| MPP2-7 | Maintenance of cell polarity, cell proliferation, synapse formation. | etinal disease, etc. | 23, 65 |
| ZO | Maintenance of cell polarity, tight junction, cell migration. | Cancer, kidney disease, etc. | 66, 67 |
| DGL5 | Maintenance of cell polarity, cell proliferation, invasion and migration, cell division. | Breast and prostate cancer, Crohn's disease, inflammatory bowel disease, etc. |
20, 22, 46, 49 |
| CARMA | Cell proliferation, inflammation, apoptosis, and metastasis. | Breast and ovarian cancer, etc. | 68, 69 |
| CACNB | Calcium- and potassium-channel | Patent ductus arteriosus | 70 |
| MAGI | Maintenance of cell polarity, invasiveness, synapse formation, apoptosis. | Human hepatocellular carcinoma cells | 23, 71 |