Table 3.
Enzymes as quorum sensing inhibitors.
| Enzyme class/ Name | Source/ Producing strain | AHLs degradation | Ref. |
|---|---|---|---|
| AHL-acylase | |||
| Acylase I | Porcine (Kidney) | C4-HSL, C6-HSL, C8-HSL, 3-oxo-C10-HSL, 3-oxo-C12-HSL | 88, 200, 201 |
| C4-HSL, C6-HSL, C8-HSL | 20, 202-204 | ||
| AiiD | Ralstonia sp. XJ12B | 3-oxo-C8-HSL, 3-oxo-C10-HSL, 3-oxo-C12-HSL | 99 |
| AiiC | Anabaena sp. PCC7120 | C4-HSL ⁓ C14-HSL | 186 |
| PvdQ | Pseudomonas sp. strain PAI-A | C10-HSL, 3-oxo-C10-HSL, C12-HSL, 3-oxo-C12-HSL, C14-HSL, C16-HSL | 183, 33 |
| HacA | P. syringae strain B728a | C8-HSL, C10-HSL, C12-HSL | 187 |
| HacB | P. syringae strain B728a | C6-HSL, C8-HSL, C10-HSL, C12-HSL | 187 |
| Aac | R. solanacearum GMI1000 | C7-HSL, C8-HSL, 3-oxo-C8-HSL, C10-HSL | 205 |
| Aac | Shewanella sp. strain MIB015 | C8-HSL, C10-HSL, C12-HSL | 206 |
| AhlM | Streptomyces sp. strain M664 | C8-HSL, C10-HSL, 3-oxo-C12-HSL | 184 |
| QuiP | P. aeruginosa | C6-HSL, C8-HSL, C10-HSL, C12-HSL | 207 |
| n.d. | Pseudomonas sp. 1A1 | C6-HSL, C8-HSL, 3-oxo-C8-HSL, 3-oxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, C12-HSL | 208 |
| AHL-lactonase | |||
| Lactonase | Human (Airway epithelia) | 3-oxo-C12-HSL | 209 |
| Gluconolactonase (GL) | As. niger IAM 2094 | Lactone ring hydrolysis | 196 |
| AttM | A. tumefaciens c58 | 3-oxo-C8-HSL | 179 |
| AiiA | Bacillus sp. 240B1 | C8-HSL | 158, 210 |
| B. anthracis (Ames strain) | C6-HSL, C8-HSL, C10-HSL | 211 | |
| B. cereus and B. mycoides | C6-HSL, C8-HSL, C10-HSL | 189 | |
| B. thuringiensis | 3-oxo-C6-HSL, C6-HSL, C8-HSL | 212 | |
| AiiB | A. tumefaciens C58 | 3-oxo-C6-HSL, C6-HSL, C8-HSL, C7-HSL, 3-oxo-C8-HSL, C8-HSL | 213 |
| AiiB | A. tumefaciens | C4-HSL, 3-oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, C10-HSL | 193 |
| GKL |
Ge. kaustophilus strain HTA426 |
C6-HSL, 3-oxo-C8-HSL, C8-HSL, C10-HSL, 3-oxo-C12-HSL | 214 |
| AiiM | M. testaceum StLB037 | 3-oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL |
215 |
| MCP | My. avium subsp. paratuberculosis K-10 | C7-HSL, C8-HSL, 3-oxo-C8-HSL, C10-HSL, C12-HSL | 216 |
| PPH | My. tuberculosis | C4-HSL, 3-oxo-C8-HSL, C10-HSL | 217 |
| AidH | Ochrobactrum sp. T63 | C4-HSL, C6-HSL, 3-oxo-C6-HSL, 3-oxo-C8-HSL, C10-HSL | 195 |
| AhlS | So. silvestris StLB046 | C10-HSL | 218 |
| SsoPox | Sul. solfataricus strain P2 | 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, 3-oxo-C12-HSL | 219, 220 |
| QsdA | Rho. erythropolis W2 | 3-oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, C12-HSL, 3-oxo-C14-HSL, C14-HSL |
221 |
| QIcA | Acidobacteria sp. | 3-oxo-C6-HSL, C6-HSL, C7-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL | 194 |
| AhlD | Arthrobacter sp. IBN110 | C4-HSL, 3-oxo-C6-HSL, C6-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL | 222 |
| Oxidoreductase | |||
| P450BM3 |
B. megaterium CYP102A1 |
Oxidizes; C12-HSL, 3-oxo-C12-HSL, C14-HSL, 3-oxo-C14-HSL, C16-HSL, C18-HSL, C20-HSL. | 181 |
| n.d. |
Burkholderia sp. strain GG4 |
Reduces; 3-oxo-AHL to corresponding 3-hydroxy derivatives. |
207 |
| n.d. | Rho. erythropolis W2 | Converts C8-HSL to C14-HSL to corresponding 3-hydroxy derivatives | 182 |
n.d.: Not determined.