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Regulatory relationship between BRCA1 and ERα. BRCA1 transcription is repressed by its own protein but can be activated by E-ER indirectly. ESR1 expression is also repressed by its own protein and activated by BRCA1 directly. BRCA1 inhibit the transactivation function of ERα via several mechanisms including mediating the ubiquitinization of ER, competitively binding to p300 and transcriptionally repress p300 expression.
