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. Author manuscript; available in PMC: 2015 May 8.
Published in final edited form as: Cell Rep. 2014 Apr 24;7(3):907–917. doi: 10.1016/j.celrep.2014.03.065

Figure 1. A Sensitized RNAi Screen to Identify Regulators Glycolytic and OXHPOS Bioenergetics.

Figure 1

(A) Depiction of the nutrient source strategy utilized in this study.

(B) Relative ATP/cell measurements from cells after a four hour treatment with DMSO, iodoacetic acid (IAA, 10 μM), or rotenone (500 nM). Error bars represent SD values.

(C) Compliment of metabolic pathways and functions targeted in the RNAi screen.

(D) RNAi screen results. Labeled data points indicate siRNAs that increased or decreased ATP levels 25% or more compared to control siRNAs in all four conditions.

See also Figure S1.