Table 2.
Concentration-Dependent Inhibition of Cell Proliferation by EPZ004777 in Various Cell Types
| MLL Gene Fusion | Cell Type | IC50 (μM)a | 95% Confidence Interval for IC50 (μM) |
|---|---|---|---|
| MLL-AF4 | RS4;11 | 6.47 | 4.22–9.94 |
| MLL-AF4 | SEM | 1.72 | 1.21–2.46 |
| MLL-AF4 | MV4-11 | 0.17 | 0.15–.19 |
| MLL-AF9 | THP-1 | 3.36 | 2.51–3.80 |
| MLL-AF9 | MOLM-13 | 0.72 | 0.65–0.80 |
| MLL-ENL | KOPN-8 | 0.62 | 0.49–0.79 |
| Nonrearranged | REH | 13.90 | 8.25–23.46 |
| Nonrearranged | Kasumi-1 | 32.99 | 30.03–36.24 |
| Nonrearranged | 697 | 36.57 | 34.77–38.46 |
| Nonrearranged | HL-60 | >50 | NA |
| Nonrearranged | Jurkat | >50 | NA |
| Nonrearranged | U937 | >50 | NA |
a
IC50 is the concentration of compound that results in a half-maximal degree of inhibition.