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. Author manuscript; available in PMC: 2014 Jun 5.
Published in final edited form as: Science. 2011 Nov 18;334(6058):982–986. doi: 10.1126/science.1211037

Figure 4. SR inactivation improves antibiotic efficacy in murine infections, and blocks the emergence of resistant mutants.

Figure 4

A. Ofloxacin treatment is more effective against lethal infections produced by the ΔrelA spoT strain than in infections caused by wild-type or ΔrelA spoT pqsA P. aeruginosa. Graphs represent pooled data from three independent experiments, with at least 15 mice per group. P ≤0.005 (*) versus treated wild-type infections.

B. Ofloxacin treatment is more effective in subcutaneous biofilm infections if the SR is inactivated. Graphs represent pooled data from two independent experiments, with at least six mice per group. Error bars indicate SEM. P ≤0.001 (*) versus treated wild-type infections.

C. Resistant mutants emerge after prolonged exposure to ofloxacin in the wild-type (➄), but not the ΔrelA spoT strain (➉). P ≤0.005 (*) versus wild type.