Table 5. Hazard Ratios (HR) and Coefficient of Variation (CV)a for Final Models for All-Cause and Breast Cancer-Specific Mortality Models in the CBCSC.
| Overall Mortality | Breast Cancer-Specific Mortality | |||
|---|---|---|---|---|
| Variable | Attained Age HR a |
95% CI | Attained Age HRa |
95% CI |
| Age at diagnosisb | ||||
| 40 | 0.67 | 0.19-2.31 | 0.47 | 0.08-2.61 |
| 50 | 0.92 | 0.52-1.63 | 0.66 | 0.29-1.48 |
| 60 | 1.00 | 1.00 | ||
| 70 | 0.92 | 0.54-1.56 | 1.62 | 0.76-2.34 |
| 80 | 0.75 | 0.27-2.12 | 2.76 | 0.62-12.2 |
| Stage (AJCC)c | ||||
| I | 1.00 | 1.00 | ||
| II | 1.22 | 1.09-1.37 | 1.76 | 1.46-2.12 |
| III | 1.97 | 1.62-2.40 | 3.14 | 2.41-4.09 |
| IV | 4.79 | 3.82-6.00 | 7.98 | 5.94-10.7 |
| Unknown | 0.97 | 0.77-1.23 | 1.26 | 0.90-1.78 |
| Grade | ||||
| I | 1.00 | 1.00 | ||
| II | 1.16 | 1.03-1.31 | 1.61 | 1.29-2.02 |
| III/IV | 1.53 | 1.35-1.73 | 2.59 | 2.07-3.25 |
| Unknown | 1.14 | 0.99-1.33 | 1.60 | 1.23-2.09 |
| Nodal involvement | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.55 | 1.39-1.73 | 1.96 | 1.69-2.28 |
| Unknown | 1.80 | 1.53-2.12 | 2.30 | 1.81-2.91 |
| Tumor size (cm) | ||||
| <1 | 1.00 | 1.00 | ||
| 1-<5 | 1.24 | 1.09-1.41 | 1.88 | 1.46-2.43 |
| ≥5 | 1.41 | 1.16-1.71 | 2.22 | 1.64-3.01 |
| Unknown | 1.69 | 1.37-2.09 | 2.65 | 1.92-3.64 |
| Surgery type | ||||
| No surgery | 1.00 | 1.00 | ||
| Mastectomy | 0.58 | 0.48-0.71 | 0.50 | 0.39-0.64 |
| Lumpectomy | 0.50 | 0.41-0.61 | 0.41 | 0.32-0.53 |
| Other | 0.66 | 0.29-1.53 | 0.53 | 0.17-1.73 |
| ER/PR c status | ||||
| ER+/PR+ | 1.00 | 1.00 | ||
| ER+/PR- | 1.22 | 1.08-1.37 | 1.30 | 1.10-1.54 |
| ER-/PR+ | 0.99 | 0.76-1.28 | 1.08 | 0.78-1.49 |
| ER-/PR- | 1.35 | 1.21-1.50 | 1.46 | 1.28-1.67 |
| ER/PR Unknown | 1.10 | 0.99-1.22 | 1.21 | 1.04-1.40 |
| Chemotherapy | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.20 | 1.09-1.32 | 1.27 | 1.11-1.46 |
| Unknown | 0.92 | 0.68-1.24 | 1.00 | 0.68-1.48 |
| Radiation therapy | ||||
| No | NId | 1.00 | ||
| Yes | 1.11 | 0.98-1.25 | ||
| Prior tumor | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.45 | 1.28-1.64 | 1.23 | 1.01-1.50 |
| Neighborhood SES c | ||||
| Lowest | 1.00 | 1.00 | ||
| Lower-middle | 1.01 | 0.89-1.15 | 0.96 | 0.80-1.15 |
| Middle SES | 0.92 | 0.81-1.05 | 0.85 | 0.71-1.02 |
| Higher-middle | 0.78 | 0.68-0.90 | 0.78 | 0.65-0.94 |
| Highest | 0.84 | 0.72-0.97 | 0.77 | 0.64-0.94 |
| Unknown | 0.85 | 0.66-1.10 | 0.82 | 0.57-1.18 |
| Race/ethnicity | ||||
| Non-Latina White | 1.00 | 1.00 | ||
| African American | 1.02 | 0.91-1.15 | 1.13 | 0.97-1.33 |
| Latina | 0.75 | 0.65-0.87 | 0.84 | 0.70-1.00 |
| Asian American | 0.76 | 0.57-1.01 | 0.60 | 0.37-0.97 |
| Other | 0.96 | 0.62-1.47 | 1.00 | 0.51-1.95 |
| Marital status | ||||
| Single, never married | 1.00 | 1.00 | ||
| Married | 0.94 | 0.83-1.05 | 1.05 | 0.90-1.22 |
| Separated/Divorced | 1.20 | 1.04-1.37 | 1.25 | 1.04-1.51 |
| Widowed | 1.11 | 0.96-1.27 | 1.25 | 1.02-1.53 |
| Unknown | 0.89 | 0.68-1.16 | 0.86 | 0.58-1.27 |
| Educational level | ||||
| <high school | 1.00 | NId | ||
| high school | 0.78 | 0.68-0.90 | ||
| some college | 0.81 (0.07) | 0.71-0.93 | ||
| college graduate or more | 0.66 (0.08) | 0.57-0.77 | ||
| Unknown | 0.71 (0.36) | 0.39-1.29 | ||
| Age at first birth | ||||
| < 20 | 1.00 | NId | ||
| 20-24 | 0.96 | 0.86-1.07 | ||
| 25-29 | 0.93 | 0.81-1.06 | ||
| 30-34 | 1.05 | 0.90-1.24 | ||
| ≥35 | 0.95 | 0.76-1.18 | ||
| Nulliparous | 1.11 | 0.97-1.27 | ||
| Missing | 1.22 | 0.93-1.61 | ||
| Smoking status | ||||
| Never | 1.00 | 1.00 | ||
| Past ≤1 pack/day | 1.11 | 1.00-1.22 | 1.15 | 1.00-1.31 |
| Past >1 pack/day | 1.37 | 1.15-1.62 | 1.18 | 0.91-1.53 |
| Current ≤1 pack/day | 1.46 | 1.28-1.68 | 1.22 | 1.01-1.47 |
| Current >1 pack/day | 2.07 | 1.60-2.69 | 1.63 | 1.11-2.38 |
| Unknown | 1.39 | 1.16-1.65 | 1.61 | 1.25-2.07 |
| Alcohol consumption | ||||
| Non-drinker | 1.00 | NId | NId | |
| ≤ 2 drinks/week | 0.84 | 0.76-0.93 | ||
| >2 drinks/week | 0.88 | 0.81-0.97 | ||
| Unknown | 1.05 | 0.88-1.28 | ||
| US born | ||||
| Yes | 1.00 | NId | NId | |
| No | 0.87 | 0.77-0.99 | ||
| Unknown | 1.26 | 0.76-2.07 | ||
| Year of diagnosis | ||||
| 1993-1995 | 1.00 | 1.00 | ||
| 1996-1998 | 0.97 | 0.87-1.09 | 0.92 | 0.79-1.07 |
| 1999-2001 | 0.85 | 0.74-0.97 | 0.80 | 0.66-0.97 |
| 2001-2004 | 0.89 | 0.75-1.05 | 0.82 | 0.66-1.07 |
| 2005-2007 | 0.84 | 0.66-1.06 | 0.81 | 0.60-1.11 |
| Residency region | ||||
| Region 1 | 1.00 | 1.00 | ||
| CSP of Orange County | 0.71 | 0.53-0.94 | 0.63 | 0.41-0.98 |
| Central California | 1.08 | 0.83-1.40 | 0.97 | 0.66-1.45 |
| CSP/Sutter Cancer Center | 0.86 | 0.69-1.08 | 0.75 | 0.54-1.05 |
| Tri-Counties | 0.79 | 0.57-1.10 | 0.79 | 0.48-1.30 |
| Desert Sierra CSP | 0.94 | 0.72-1.24 | 0.87 | 0.58-1.29 |
| Cancer Registry of N California | 1.05 | 0.82-1.36 | 0.96 | 0.65-1.43 |
| San Diego/Imperial | 1.15 | 0.89-1.49 | 0.97 | 0.65-1.44 |
| Northern California Cancer Center | 1.09 | 0.94-1.27 | 1.04 | 0.84-1.27 |
| CSP of Los Angeles | 1.09 | 0.89-1.35 | 1.05 | 0.77-1.44 |
a
95% CI
b
HR estimates for specific ages at diagnosis are computed from the Cox model regression parameters of continue Age and log (Age).
c
American Joint Committee on Cancer (AJCC), estrogen receptor(ER)/progesterone receptor (PR), socioeconomic status (SES)
d
HR estimates are not shown for variables that were not included (NI) in the final model.