Table 6. Hazard Ratios (HR) and 95% Confidence Intervals (CI)a for Overall and Breast Cancer-Specific Mortality in African Americans, Latinas, and Asian Americans Relative to Non-Latina Whites.
| Overall mortality | Breast cancer-specific mortality | |||||||
|---|---|---|---|---|---|---|---|---|
| Non-Latina Whites | African Americans | Latinas | Asian Americans | Non-Latina Whites | African Americans | Latinas | Asian Americans | |
|
| ||||||||
| HR | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Deaths | 1,561 | 739 | 470 | 266 | 703 | 439 | 261 | 161 |
| Base Modelb | 1.00 | 1.02 (0.91,1.15) | 0.75 (0.65, 0.87) | 0.76 (0.57, 1.01) | 1.00 | 1.13 (0.97, 1.33) | 0.84 (0.70, 1.00) | 0.60 (0.37, 0.97) |
| Limited Model1c | 1.00 | 1.25 (1.12,1.39) | 0.82 (0.72, 0.93) | 0.71 (0.53, 0.94) | 1.00 | 1.31 (1.13, 1.53) | 0.84 (0.71, 1.01) | 0.56 (0.35, 0.90) |
| Limited Model2d | 1.00 | 1.46 (1.33, 1.61) | 0.99 (0.89, 1.11) | 0.82 (0.71, 0.94) | 1.00 | 1.52 (1.33, 1.73) | 1.00 (0.86, 1.16) | 0.84 (0.70, 1.02) |
| Limited Model2-CCRe | 1.00 | 1.36 (1.32, 1.39) | 1.01 (0.98, 1.03) | 0.80 (0.78, 0.83) | 1.00 | 1.42 (1.37, 1.47) | 1.01 (0.99, 1.04) | 0.85 0.82, 0.89) |
95% confidence intervals for Hazard Ratios (HR) are obtained by dividing and multiplying HR by the factor M=(1+coefficient of variation)1.96
HR and 95% CI were estimated using multivariable Cox proportional hazards regression methods with attained age as the survival time and stratification by study (AABCS, CARE, SFBCS, LACE, CTS, MEC). The following variables were adjusted for in both the overall and breast cancer-specific mortality models unless otherwise specified: age at diagnosis, American Joint Committee on Cancer (AJCC) stage, grade, nodal involvement, tumor size, surgery type, estrogen receptor (ER)/progesterone receptor (PR) status, chemotherapy, radiation therapy (breast cancer-specific model only), prior tumor, neighborhood SES, race/ethnicity, marital status, education level (overall mortality model only), age at first birth (overall mortality model only) smoking, alcohol (overall model only), US born (overall model only), year of diagnosis, residence region (see Table 5)
As in footnote a, but including only main effects for race/ethnicity, age at diagnosis, registry region, AJCC stage, ER/PR status, surgery type, radiation therapy (breast cancer-specific mortality model only), and stratification by study (AABCS, CARE, SFBCS, LACE, CTS, MEC).
As in footnote b, but without stratification by study (AABCS, CARE, SFBCS, LACE, CTS, MEC).
As in footnote c, but the analysis was conducted in the entire CCR study population of 289,058 breast cancer patients diagnosed from 1993-2007.