Figure 3. Distant homologs of centrosomal proteins.

Contrary to previous reports, HAUS7 and AUG7 (a), and HAUS8 and AUG8 (b), are in fact homologs, linked by proteins from other species. Edges connect pairs of proteins that can be aligned successfully, both across and within species. Edge width corresponds to the strength (bit score) of the alignment. In both cases, chordate proteins are most similar to the human protein. Proteins from other animals, in turn, are both similar to plant and chordate proteins, and hence make it possible to detect the homology between the human and plant proteins.