Figure 7. Differences in recruitment correspond to functional differences. a.

When novel proteins are removed from the interaction network, proteins that become more distant to the centrioles can be identified. b Five high-level GO terms corresponding to the centrosome's functions were tested for enrichment among core, novel or peripheral proteins. Core proteins, which remain at the same distance, are more involved in cell cycle and division than in processes important for animals such as development and signaling. Cut-offs for significance levels (calculated with Fisher's exact test): ** 0.01, * 0.05, • 0.1.