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. 2014 Jun 5;10(6):e1004391. doi: 10.1371/journal.pgen.1004391

Figure 4. Constitutive expression of SE Parkin impairs motor behavior.

Figure 4

(A) LacZ and WT, SA or SE Parkin were expressed under the control of MHC-GAL4 in the w- background. WT and SA Parkin improved the motor activity in older flies, whereas SE Parkin compromised motor activity throughout the trials. LacZ served as a control. The values are presented as the mean ± SE from 20 trials. Male flies were used for the assay. **P<0.01 vs. LacZ; #P<0.05. Flies expressing SE Parkin had decreased climbing ability compared with flies expressing WT or SA Parkin throughout the trial (P<0.01). (B) Muscle-specific expression of Parkin SE under control of MHC-GAL4 failed to rescue the motor defect of the PINK1-/- flies. The loss of climbing ability in the PINK1-/- flies was rescued by expression of WT and SA Parkin. The values represent the mean ± SE from 20 trials. Male flies were used for the assay. **P<0.01 vs. LacZ. Flies expressing SE Parkin had decreased climbing ability compared with flies expressing WT or SA Parkin throughout the trial (P<0.01).