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. 2014 Jun 5;9(6):e97996. doi: 10.1371/journal.pone.0097996

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© 2014 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The NADPH binding site is predicted by overlapping the structure of SiaM and the structure of ActKR/NADPH complex. The NADPH molecule and the catalytic triad (Ser146, Tyr159, Lys163) are shown in sticks. The rest of SiaM is displayed as surface and colored in light gray.