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. 2014 Jun 5;9(6):e98458. doi: 10.1371/journal.pone.0098458

Figure 5. Influence of progastrin on macrophage-derived Wnt ligands.

Figure 5

Immunoreactivity to Wnt1 in the stroma of colorectal cancer in relation to the expression of gastrin in the same tissue (scale bar  = 0.2 mm) (A); and effects of the presence of progastrin during differentiation of human peripheral monocytes to macrophages on mRNA expression of three different Wnt ligands in these macrophages (B–D, n = 5) and mRNA expression of Lgr5 in co-cultured Caco-2 cells (E, n = 7). Bars represent mean ±SEM. *P<0.05 and **P<0.01 vs corresponding value in vehicle-treated cells.