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. 2014 Jun 5;9(6):e98794. doi: 10.1371/journal.pone.0098794

Figure 2. The Combined Effects of anti-PAD3/4 Cross-reactive Antibodies and Smoking Were Robust Indicators of Radiographic RA-ILD.

Figure 2

The cohort was grouped based on the presence of anti-PAD3/4XR (closed markers) and history of ever smoking (i.e. current or former smokers). The association of anti-PAD3/4XR with ILD was stronger among ever smokers compared to never smokers in both crude (Panel A) and adjusted (Panel B) analyses. Average probabilities and 95% confidence intervals are depicted. Panel B associations adjusted for age, gender, rheumatoid factor and CCP2 seropositivity, DAS28, current use of methotrexate and prednisone, RA duration, and total Sharp-van der Heijde Score.