Skip to main content
. 2014 Jun 5;10(6):e1004149. doi: 10.1371/journal.ppat.1004149

Figure 7. Down-regulation of Dusp3 and Psme3 in A/J is associated with over-production of pro-inflammatory cytokines.

Figure 7

Both Dusp3 and Psme3 inhibit NF-κB activity, which is responsible for the production of inflammatory cytokines. The reduced expression of Dusp3 and Psme3 in A/J mice is associated with elevated NF-κB activity, which leads to increased inflammatory cytokines. Dusp3 and Psme3, together with other factors from murine chromosome 8 and 18, contribute to S. aureus susceptibility of A/J strain.