Figure 6. SOX2⁺ cells are present in adult temporal lobe white matter.

SOX2⁺ cells can be found scattered within white matter. We do not detect NeuN⁺/SOX2⁺ neuronal cells (A), Iba-1⁺/SOX2⁺ microglial cells (B), or CNPase⁺/SOX2⁺ differentiated oligodendrocytes (C). Although the vast majority of SOX2⁺ cells were GFAP⁻ (D), some of them were GFAP⁺ astrocytes with more activated morphology (E). F. Finally, most of the SOX2⁺ cells corresponded to OLIG2^high, which are thought to be oligodendrocyte progenitor cells in adult brain white matter. SOX2⁺/OLIG2^low and SOX2⁺/OLIG2⁻ could be also found in all samples. The scale bars represent 20 µm. Glioblastoma sections used as positive controls are collected in Figure S6.