Figure 7. Schematic diagram representing our hypothesis about SOX2⁺ cell evolution in vitro.

According to our findings, we hypothesise that SOX2⁺ cells correspond to glial restricted progenitors, spontaneously differentiating to O4⁺ pre-oligodendrocytes that finally lose SOX2 expression. In addition, a small number of GFAP⁺ astrocytes is generated. Finally, after exposure to the appropriate growth factors, SOX2⁺ cells are able to generate oligodendrocytes that express mature myelinating oligodendrocyte proteins such as MBP.