Table 1. Subject cohort demographics.
Fifty-seven tissues (indicated by specimen ID’s; SIDs) from 45 subjects (indicated by patient ID’s; PIDs) were included in this study. Gender, subject’s highest disease state, specimen location, and consensus tissue type for the metaplastic tissues are listed. Specimens included in the SNP array and Ion AmpliSeq re-sequencing specimens are indicated along with goblet-cell (GC) score (0= none, 1= rare, 2 = common, 3 = numerous) for each tissue and the NGM sub-types. PID= patient ID, SID= Specimen ID; GEJ= Gastro-esophageal junction; Eso= Esophagus; NGM= non-goblet metaplasia; IM= intestinal metaplasia; CM= cardiac mucosa; OCM= oxynto-cardiac mucosa; CM-OCM= Mixture of CM and OCM type.
| Patient Information | Specimen Information | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| PID | Gender | Advanced Disease State |
SID | Location | Tissue type | SNP | Ion Torrent |
GC Score |
NGM Sub-type |
| 4 | M | EAC | UR109 | GEJ | NGM | Y | Y | 0 | CM |
| 12 | M | IM | UR28 | GEJ | Composite | Y | Y | 3,0 | CM |
| 18 | M | LGD | UR58 | Eso | NGM | Y | Y | 0 | CM-OCM |
| 27 | M | EAC | UR550 | Eso | NGM | Y | - | 0 | OCM |
| 31 | M | LGD | UR84 | Eso | IM | Y | Y | 3 | N/A |
| 36 | M | HGD | UR99 | Eso | NGM | Y | Y | 0 | CM-OCM |
| 37 | F | IM | UR103 | Eso | Composite | Y | Y | 3,0 | N/A |
| 39 | M | EAC | UR117 | Eso | NGM | Y | Y | 0 | CM-OCM |
| 41 | M | LGD | UR122 | Eso | IM | Y | Y | 3 | N/A |
| 43 | M | HGD | UR194 | Eso | NGM | Y | Y | 0 | OCM |
| 44 | F | IM | UR309 | Eso | NGM | Y | Y | 0 | CM-OCM |
| 45 | F | NGM | UR128 | GEJ | NGM | Y | Y | 0 | CM-OCM |
| 50 | M | LGD | UR151 | GEJ | IM | Y | Y | 3 | N/A |
| UR152 | GEJ | NGM | Y | Y | 0 | CM-OCM | |||
| UR158 | GEJ | NGM | Y | Y | 0 | CM-OCM | |||
| 55 | M | LGD | UR159 | GEJ | Composite | Y | Y | 3,0 | CM |
| UR162 | Eso | IM | Y | Y | 3 | N/A | |||
| 56 | M | EAC | UR165 | GEJ | NGM | Y | Y | 0 | CM-OCM |
| 59 | M | EAC | UR218 | Eso | IM | Y | Y | 3 | N/A |
| 61 | M | LGD | UR301 | Eso | NGM | Y | Y | 0 | CM-OCM |
| 63 | M | IM | UR342 | Eso | NGM | Y | Y | 0 | OCM |
| 66 | M | EAC | UR182 | GEJ | NGM | Y | - | 0 | CM-OCM |
| 67 | M | EAC | UR199 | Eso | IM | Y | Y | 3 | N/A |
| UR221 | GEJ | Composite | Y | Y | 3,0 | CM | |||
| 68 | M | IM | UR222 | Eso | NGM | Y | Y | 0 | CM-OCM |
| UR223 | Eso | IM | Y | Y | 3 | N/A | |||
| 87 | F | IM | UR269 | Eso | IM | Y | Y | 3 | N/A |
| UR286 | Eso | Composite | Y | Y | 1,0 | CM | |||
| 89 | M | IM | UR289 | Eso | IM | Y | Y | 3 | N/A |
| 92 | M | HGD | UR649 | Eso | IM | Y | Y | 3 | N/A |
| UR274 | Eso | NGM | Y | Y | 0 | OCM | |||
| 94 | M | HGD | UR284 | GEJ | NGM | Y | Y | 0 | CM-OCM |
| 95 | M | IM | UR291 | GEJ | NGM | Y | Y | 0 | CM |
| UR627 | Eso | Composite | Y | - | 3,0 | CM | |||
| 104 | M | HGD | UR771 | Eso | NGM | Y | - | 0 | CM-OCM |
| UR773 | Eso | IM | Y | - | 3 | N/A | |||
| 111 | F | LGD | UR482 | Eso | IM | Y | Y | 2 | N/A |
| 116 | M | HGD | UR369 | GEJ | NGM | Y | Y | 0 | CM-OCM |
| 124 | F | HGD | UR402 | Eso | IM | Y | - | 3 | N/A |
| UR582 | Eso | NGM | Y | - | 0 | CM-OCM | |||
| 165 | M | HGD | UR762 | Eso | IM | Y | - | 2 | N/A |
| 169 | M | EAC | UR637 | GEJ | NGM | Y | Y | 0 | CM-OCM |
| UR776 | Eso | IM | Y | Y | 3 | N/A | |||
| 172 | M | LGD | UR653 | Eso | IM | Y | - | 1 | N/A |
| 188 | M | HGD | UR727 | GEJ | NGM | Y | Y | 0 | CM-OCM |
| UR931 | Eso | IM | Y | Y | 3 | N/A | |||
| 209 | M | HGD | UR830 | Eso | NGM | Y | - | 0 | CM |
| 211 | M | IM | UR840 | Eso | IM | Y | - | 3 | N/A |
| 213 | M | EAC | UR242 | Eso | NGM | Y | Y | 0 | CM-OCM |
| 217 | M | HGD | UR881 | GEJ | IM | Y | - | 3 | N/A |
| 221 | M | LGD | UR937 | Eso | IM | Y | - | 2 | N/A |
| 222 | M | HGD | UR946 | Eso | IM | Y | - | 1 | N/A |
| 261 | M | LGD | UR1137 | Eso | IM | Y | - | 3 | N/A |
| UP1034 | M | EAC | 4938 | Eso | IM | Y | Y | 3 | N/A |
| UP1064 | M | EAC | 4936 | Eso | IM | Y | Y | 2 | N/A |
| UP1066 | M | EAC | 4937 | Eso | IM | Y | Y | 3 | N/A |
| UP163 | M | EAC | 1881 | Eso | IM | Y | Y | 1 | N/A |