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. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Gene Ther. 2014 Apr 10;21(6):599–608. doi: 10.1038/gt.2014.33

Fig. 5 — Mice were treated with MOG, PLP, MBP, or HSV-IL-2 as described in Figure 1 above. Some of the treated mice were injected with IFN-β DNA or infected ocularly with 2X10⁷ PFU/eye of HSV-IL-12p70 as described in Materials and Methods. On day 29 post-treatment with MOG, PLP, MBP or HSV-IL-2, the brains, ONs and SCs were collected, fixed, sectioned, and stained with LFB. Representative photomicrographs are shown. 10X direct magnification. Arrows indicate areas of demyelination. Panels: (A) Effects of IFN-β on blocking CNS demyelination; and (B) Effects of HSV-IL-12p70 on blocking CNS demyelination.

Fig. 5 — Mice were treated with MOG, PLP, MBP, or HSV-IL-2 as described in Figure 1 above. Some of the treated mice were injected with IFN-β DNA or infected ocularly with 2X10⁷ PFU/eye of HSV-IL-12p70 as described in Materials and Methods. On day 29 post-treatment with MOG, PLP, MBP or HSV-IL-2, the brains, ONs and SCs were collected, fixed, sectioned, and stained with LFB. Representative photomicrographs are shown. 10X direct magnification. Arrows indicate areas of demyelination. Panels: (A) Effects of IFN-β on blocking CNS demyelination; and (B) Effects of HSV-IL-12p70 on blocking CNS demyelination.