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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Alcohol Clin Exp Res. 2014 Apr 14;38(6):1540–1549. doi: 10.1111/acer.12405

Figure 3. Genome-wide changes in methylation in (A) gene bodies and (B) promoters, CpG islands (CGIs), and CGI shores.

Figure 3

The average methylation was computed for each gene/promoter/CGI and CGI shore within each of the three groups, and differences among groups were plotted as density histograms. As shown in the left box for gene bodies, ethanol diet samples had on average 1.2% less methylation than betaine supplemented diet samples, whereas control diet samples had on average 1.5% greater methylation than ethanol diet samples. As shown in the right box, ethanol and betaine treatments did not change methylation levels in promoters, CG Islands (CGI), or CGI shores.