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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Genes Immun. 2014 Feb 27;15(4):218–223. doi: 10.1038/gene.2014.7

Table 4.

Multivariate analysis of the four genes, including main effects and two gene-gene interactions, using the T1DGC data.

Variable GRR (95% CI) P-value
MGAT1 IVA/VT-T 1.08 (0.80-1.46) 0.63
CTLA-4 1.19 (1.10-1.28) 2.5×10−5
IL2RA 1.21 (1.11-1.33) 2.1 ×10−5
IL7RA 1.10 (1.00-1.20) 4.0×10−2
MGAT1 IVA/VT-T × CTLA-4 1.58 (1.14-2.18) 6.0×10−3
MGAT1 VA/VT-T × (IL=4) 0.76 (0.60-0.97) 2.7×10−3

The p-value (LRT) for the two interaction terms is 2.0×10−3. The p-value (LRT) for the joint effect and additive and non-additive effects is 3.9×10−10.