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. Author manuscript; available in PMC: 2015 Feb 26.
Published in final edited form as: J Am Chem Soc. 2014 Feb 11;136(8):3176–3183. doi: 10.1021/ja411733s

Figure 3.

Figure 3

Irreversible inhibition of Pol β by 3a. A) Relative Pol β lyase activity on 32P-15 as a function of [3a] and preincubation time of inhibitor with enzyme. B) IC50 of Pol β inactivation following 30 min preincubation with 3a.