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. Author manuscript; available in PMC: 2015 Jul 5.
Published in final edited form as: Eur J Pharmacol. 2014 Apr 12;734:98–104. doi: 10.1016/j.ejphar.2014.04.004

Table 3.

Computer simulated CI and DRI values for VN/14-1 and thapsigargin

Inhibition % CI DRI VN/14-1 DRI Thapsigargin
50 0.658 1.751 11.498
75 0.317 3.503 31.584
95 0.095 11.235 172.494

The synergism analysis of VN/14-1 with thapsigargin was performed with Chou–Talalay’s combination index and multiple drug-dose effect analysis method as described in Methods section. The values were determined using computer program from the data from the MTT assays. Combination index (CI): CI < 1, =1, and >1 indicates synergism, additive effect, and antagonism, respectively. Dose reduction index (DRI): fold of dose reduction for each drug in combination, for a given degree of inhibition, when compared with the dose of each drug alone for the same degree of inhibition.