Table 4.

Zanamivir Pharmacokinetic Parameter Estimates by Renal Function Group for Initial 600-mg Dose on Day 1^a

CLcr, mL/minb	Geometric Mean (%CV) [No. of Patients]
	Cmax, μg/mL	AUC(0-∞) , h · µg/mL	t1/2, h	CL, mL/min	Vss. L
≥80	32.8 (34) [67]	82.9 (36) [63]	2.39 (31) [67]	121 (36) [63]	22.0 (30) [63]
50 to <80	34.2 (19) [15]	120 (38) [15]	3.47 (73) [18]	83.4 (38) [15]	21.3 (20) [15]
30 to <50	37.7 (34) [13]	244 (27) [12]	6.11 (30) [13]	40.9 (27) [12]	20.7 (41) [12]
15 to <30	36.9 (23) [5]	729 (77) [5]	19.0 (72) [5]	13.7 (77) [5]	22.6 (23) [5]
<15	47.1 (…) [2]	950 (…) [2]	18.4 (…) [2]	10.5 (…) [2]	16.3 (…) [2]

Abbreviations: %CV, percent coefficient of variation; AUC_(0-∞), area under the serum concentration-time curve extrapolated to infinity; CL, systemic clearance of zanamivir; CLcr, creatinine clearance; C_max, peak concentration at end of infusion; t_½, elimination half-life; V_ss, steady-state volume of distribution.

^a Because of missed samples, not all pharmacokinetic parameters could be estimated for all patients.

^b Denotes renal function as either CLcr or clearance estimated for continuous renal replacement therapy modality (CL_CRRT), n = 4.