Table 3.
Diagnostic performance comparisons in case-based and lesion-based analyses
|
PET/CT and CT in all patients |
PET/CT in patients with different CEA levels |
|||
| PET/CT | CT | PET/CT (CEA ≤ 3.4 ng/mL) | PET/CT (CEA > 3.4 ng/mL) | |
| Case-based analysis | ||||
| Sensitivity (%) | 95.2 (79/83)1 | 80.7 (67/83)1 | 83.3 (10/12) | 97.2 (69/71) |
| Specificity (%) | 82.6 (19/23) | 73.9 (17/23) | 85.7 (12/14) | 77.8 (7/9) |
| Accuracy (%) | 92.5 (98/106)2 | 79.3 (84/106)2 | 84.6 (22/26) | 95 (76/80) |
| Lesion-based analysis | ||||
| Sensitivity (%) | 96.1 (146/152)3 | 83.1 (118/142)3 | 81.3 (13/16)5 | 97.8 (133/136)5 |
| Specificity (%) | 81.4 (35/43) | 73.5 (25/34) | 80 (16/20) | 82.6 (19/23) |
| Accuracy (%) | 92.8 (181/195)4 | 81.3 (143/176)4 | 80.6 (29/36)6 | 95.6 (152/159)6 |
1
χ2 = 8.186, P = 0.004;
2
χ2 = 6.201, P = 0.013;
3
χ2 = 13.445, P = 0.000;
4
χ2 = 11.194, P = 0.001;
5
χ2 = 6.432, P = 0.011;
6
χ2 = 7.837, P = 0.005. PET: Positron emission tomography; CT: Computerized tomography; CRC: Colorectal cancer.