Table 1.
Main clinical and demographic characteristics of the subjects n (%)
| Characteristics | Total, n = 115 | S0, n = 66 | S1, n = 33 | S2-S3, n = 16 |
| Sex, females | 30 (24.1) | 16 (24.2) | 10 (30.3) | 4 (25.0) |
| Age, yr (mean ± SD) | 43.1 ± 10.5 | 41.3 ± 11.0 | 46.8 ± 8.6 | 43.0 ± 11.1 |
| BMI, kg/m2 (mean ± SD) | 24.8 ± 4.2 | 24.0 ± 3.5 | 25.6 ± 5.2 | 26.7 ± 3.6 |
| BMI ≥ 25 kg/m2 | 57 (50.0) | 28 (42.4) | 18 (56.2) | 11 (68.7) |
| AST, IU/L (IQR) | 43 (28-73) | 39 (25-59) | 52 (31-88) | 45 (35-73) |
| ALT, IU/L (IQR) | 63 (38-110) | 54 (33-73) | 70 (38-142) | 98 (63-125) |
| Alkaline phosphatase, IU/L (mean ± SD) | 72.2 ± 25.5 | 77.1 ± 27.8 | 65.4 ± 16.9 | 62.6 ± 24.6 |
| GGT, IU/L (IQR) | 48 (26-88) | 39 (20-57) | 58 (32-133) | 73 (40-106) |
| Total bilirubin, μmol/L (IQR) | 0.69 (0.49-0.92) | 0.70 (0.46-1.06) | 0.64 (0.55-0.92) | 0.70 (0.54-0.86) |
| Platelets count, 103/mm3 (mean ± SD) | 221 ± 78 | 229 ± 81 | 204 ± 66 | 223 ± 90 |
| Prothrombin time, % (mean ± SD) | 93.9 ± 12.6 | 93.4 ± 11.5 | 94.2 ± 15.0 | 95.4 ± 12.2 |
| HCV infection | 82 (71.3) | 44 (66.7) | 26 (78.8) | 12 (75.0) |
| HBV infection | 28 (24.3) | 18 (27.3) | 7 (21.2) | 3 (18.7) |
| HCV/HIV infection | 5 (4.3) | 4 (6.1) | 0 (0) | 1 (6.2) |
| Fibrosis score (Metavir) | ||||
| F0 | 14 (12.2) | 9 (13.6) | 5 (15.1) | 0 (0) |
| F1 | 42 (36.5) | 29 (43.9) | 7 (21.2) | 6 (37.5) |
| F2 | 31 (27.0) | 17 (25.8) | 10 (30.3) | 4 (25.0) |
| F3 | 18 (15.6) | 9 (13.6) | 7 (21.2) | 2 (12.5) |
| F4 | 10 (8.7) | 2 (3.0) | 4 (12.1) | 4 (25.0) |
| Activity grade (Metavir) | ||||
| A0 | 12 (10.4) | 8 (12.1) | 3 (9.1) | 1 (6.2) |
| A1 | 66 (57.4) | 43 (65.1) | 14 (42.4) | 9 (52.2) |
| A2 | 19 (16.5) | 7 (10.6) | 9 (27.3) | 3 (18.7) |
| A3 | 18 (15.6) | 8 (12.1) | 7 (21.2) | 3 (18.7) |
| LSM, kPa (IQR) | 6.7 (5.1-9.1) | 6.4 (4.9-8.4) | 6.7 (4.8-9.5) | 8.0 (5.6-11.1) |
| CAP, dB/m (mean ± SD) | 244.4 ± 49.1 | 227.1 ± 43.1a | 254.6 ± 38.9b | 297.8 ± 49.4d |
SD values represent mean, and interquartile range (IQR) values represent median.
a
P < 0.05 (S0 vs S1);
b
P < 0.01 (S1 vs S2-S3);
d
P < 0.01 (S0 vs S2-S3). BMI: Body mass index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; CAP: Controlled attenuation parameter; LSM: Liver stiffness measurement.