Table 1.
Univariate analysis of survival, according to the clinicopathological factors of patients who underwent surgical resection (R0, R1 and R2) for mid-distal extrahepatic bile duct cancer n (%)
| Variables |
Total (n = 133) |
||||
| No. | 5 yr survival | Median | P value | ||
| Age | Mean 65.8 | ||||
| ≤ 70 | 86 (64.7) | 39.1 | 41.0 | 0.917 | |
| > 70 | 47 (35.3) | 44.8 | 38.0 | ||
| Sex | M | 81 (60.9) | 33.6 | 36.0 | 0.359 |
| F | 52 (39.1) | 59.4 | 105.0 | ||
| CA19-9 (U/mL) | ≤ 35 | 27 (30) | 57.9 | 85.0 | 0.734 |
| > 35 | 63 (70) | 44.9 | 37.0 | ||
| Type of resection | PD | 90 (67.7) | 47.2 | 59.0 | 0.105 |
| BDR | 43 (32.3) | 30.0 | 32.0 | ||
| T classification | Tis, T1 | 38 (29.7) | 52.3 | 63.0 | 0.144 |
| T2 | 25 (19.5) | 56.8 | - | ||
| T3 | 65 (50.8) | 34.1 | 36.0 | ||
| N classification | N0 | 96 (75.0) | 51.3 | 63.0 | 0.033 |
| N1 | 32 (25.0) | 17.0 | 30.0 | ||
| M classification | M0 | 130 (97.7) | 42.2 | 41.0 | 0.242 |
| M1 | 3 (2.3) | 0 | 16.0 | ||
| TNM stage | 0, I | 51 (39.5) | 64.5 | 105.0 | 0.006 |
| II | 75 (58.1) | 30.1 | 36.0 | ||
| III | 0 (0) | - | - | ||
| IV | 3 (2.3) | 0 | 16.0 | ||
| PNI | - | 75 (58.6) | 55.8 | 105.0 | 0.022 |
| + | 53 (41.4) | 17.5 | 38.0 | ||
| LVI | - | 103 (80.5) | 52.3 | 63.0 | 0.000 |
| + | 25 (19.5) | 6.7 | 23.0 | ||
| Resection margin | R0 | 102 (76.7) | 49.0 | 59.0 | 0.000 |
| R1 | 24 (18.0) | 21.0 | 31.0 | ||
| R2 | 7 (5.3) | 0 | 12.0 | ||
| Differentiation | Papillary | 4 (3.2) | 66.7 | 105.0 | 0.409 |
| W/D | 40 (32.5) | 48.8 | 59.0 | ||
| M/D | 66 (53.7) | 36.7 | 36.0 | ||
| P/D | 13 (10.6) | 56.1 | 63.0 | ||
PD: Pancreatoduodenectomy; BDR: Segmental bile duct resection; W/D: Well differentiated; M/D: Moderately differentiated; P/D: Poorly differentiated; LVI: Lymphovascular invasion; PNI: Perineural invasion.