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Part of the MVA pathways discovered thus far from the archaea. A, classical pathway identified in S. solfataricus (11). B, modified pathway that was expected thus far and was recently identified in H. volcanii (10) (and in a Cloroflexi bacterium (9)). C, modified pathway identified in T. acidophilum in this study. The conversion from MVA-3-P to IP is likely catalyzed by unidentified enzymes, probably via MVA-3,5-PP.
