TABLE 3.

Spectrum of antibacterial activity for different classes of FabI inhibitors

Organism	Enoyl-reductase isoforma	MIC (μm) PT01	MIC (μm) CG400549	MIC (μm) PT166
S. aureus RN4220	FabI	2.3	5.9	0.8
E. coli MG1655	FabI	18.7	>375	>425
E. coli MG1655 ΔacrABb	FabI	0.6	>375	6.7
F. tularensis LVS	FabI	0.1c	5.9	0.4
P. mirabilis ATCC35659	FabI	NDd	>750	213.8
M. tuberculosis H37Rv	FabI	72.9	>300	10.5
B. pseudomallei Bp400b	FabI and FabV	326.7e	376.0	213.8

^a Data are according to Refs. 23, 24, 29, 81.

^b Strains with knock-out of specific efflux pumps are shown.

^c Data are according to Ref. 69.

^d ND means not determined.

^e Data are according to Ref. 35.