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Effect of RNase H inhibitors on DNA synthesis by HIV-1 RT. A, sequence of polymerase-dependent substrate used in this assay. * indicates 5′- radiolabeled primer. B, time course of DNA synthesis (0–10 min) in the absence and presence of PFA, GSK5750, and β-thujaplicinol. C, results from B shown graphically. Polymerase activity in the absence of inhibitor (○), with GSK5750 (×), with β-thujaplicinol (♦), and with PFA (□) was plotted and fitted to a single exponential function.
