FIGURE 3.

A stick diagram and space-filling model of the AAPP with 8H7 Fab. A, stereo view of the interactions between AAPP and the heavy and light chains of the 8H7 Fab. For Tyr-32 of the heavy chain and Tyr 37 of the light chain the van der Waals volume of the side chain is indicated by a dotted surface. B, two-dimensional plot of the interactions between AAPP and the 8H7 Fab. Hydrogen bonds are shown as red dotted lines, and hydrophobic interactions are shown as arcs. C, molecular surface of the 8H7 Fab bound to AAPP, colored by charge with red negative and blue positive. The AAPP itself is shown as a green ribbon trace with the turn between helices fitting into pockets on the antibody surface.