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. 2014 Apr 28;289(23):16313–16325. doi: 10.1074/jbc.M114.554212

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Hp 2-2 confers a paradoxical pro-oxidant activity against Hb-mediated oxidation of LDL at acidic pH in vitro. Data represent the mean ± S.E. of three independent experiments. Data are presented as a percentage inhibition of Hb-induced LDL oxidation conferred by Hp. There was a severe impairment in the antioxidant activity of Hp 2-2 against LDL oxidation and even a paradoxical increase in LDL oxidation specifically at acidic pH with a more dramatic impairment associated with glycosylated Hb (Gly. Hb) and oxidized Hb (met-Hb) as compared with native Hb (oxy-Hb).