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. 2014 Apr 25;289(23):16374–16388. doi: 10.1074/jbc.M113.539601

FIGURE 9.

FIGURE 9.

Myeloid cell-specific Per1/2 disruption exacerbates diet-induced insulin resistance and glucose intolerance. Chimeric mice (BMT-WT and BMT-Per1ldc/Per2ldc) were fed an HFD for 12 weeks (n = 6–10). A, body weight was monitored before and after HFD feeding. B, food intake was recorded during the feeding period and calculated as food consumption (g) per day per mouse. Right panel, feeding efficiency was calculated as the ratio of food intake to body weight. C, plasma levels of insulin. D, plasma levels of glucose. E, insulin tolerance tests. F, glucose tolerance tests. For A–F, data are the means ± S.E. *, p < 0.05; **, p < 0.01 BMT-Per1ldc/Per2ldc versus BMT-WT (B–D) under the same conditions (A) or time points (E and F). For C–F, HFD-fed chimeric mice were fasted for 4 h starting at the same time of the day before tissue collection or physiological assays. For E and F, mice were given a peritoneal injection of insulin (1 unit/kg) (E) or glucose (2 g/kg) (F).