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Organization of the V-ATPase and structure of PA1b. A, the reconstruction of the M. sexta V-ATPase from cryo-EM data (11) with crystal structures of homologous subunits fitted and labeled. B, primary structure of the insecticidal peptide PA1b. Lines indicates the connectivity of the disulfide bridges. C, three-dimensional structure of PA1b (Protein Data Bank ID code 1P8B) (20) showing α-helical (red), β-sheet (yellow), and random coil (green regions). Disulfides are colored cyan.
