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. 2014 Apr 15;289(23):16516–16525. doi: 10.1074/jbc.M113.539031

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — GLI1 regulates FAS and FASL expression in pancreatic tumors. A, mRNA expression analysis by qPCR in mouse pancreas 30 days post-partum showed that FAS and FASL levels are reduced in GKO/KPC group compared with the KPC group. B–G, qPCR analysis of the components of the Sonic Hedgehog pathway in mouse pancreas. B, as expected, GLI1 expression was reduced in the GKO/KPC. C–G, GLI2 (C), GLI3 (D), PATCHED1 (F), and SMOOTHENED (G) showed as well a reduced expression in the GKO/KPC compared with KPC. SHH levels did not change in both experimental groups.