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The PH and/or coiled-coil domains of GRF1 determine whether GRF proteins induce HFS-LTP. A and B, HFS-LTP was generated in hippocampal brain slices from WT mice and DBKO mice re-expressing indicated GRF proteins or various GRF1/GRF2 chimeras. Data show quantified average fEPSP slopes from at least 6 slices from 4 mice and data show mean ± S.E.
