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. 2014 Apr 22;289(23):16551–16564. doi: 10.1074/jbc.M114.557959

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — The IQ domain of GRF1 is necessary and sufficient for GRF proteins to induce LFS-LTD. LFS-LTD was generated in hippocampal brain slices from DBKO mice re-expressing various GRF proteins and chimeras. Panels A and B show fEPSP slopes representative of results from at least 6 slices from 3 mice each. Panels C and D show quantified average fEPSP slopes from at least 5 slices from 3 mice and data show mean ± S.E. *, p ≤ 0.05; ***, p ≤ 0.001; n.s., not statistically different; inset, a comparison of the IQ motif sequences between GRF1 and GRF2 with differences marked.