TABLE 1.
List of biochemical reactions and reaction rates used in our model for receptor-receptor and TRAIL-receptor interaction
(TRAILR1)2, (TRAILR4)2, and TRAILR1-TRAILR4 denote the receptor dimers, and (TRAILR1)2-TRAIL, (TRAILR4)2-TRAIL, and TRAILR1-TRAILR4-TRAIL denote TRAIL receptor complexes. The rates of R6 are estimated as geometric mean of the rates if R4 and R5: kon,6 = (kon,4 × kon,5)1/2, koff,6 = (koff,4 × koff,5)1/2.
| Reactions | kon | koff | |
|---|---|---|---|
| nm−1 × s −1 | s−1 | ||
| R1 | 2 × TRAILR1 ↔ (TRAILR1)2 | 1.15 × 102 | 5.43 × 10−2 |
| R2 | 2 × TRAILR4 ↔ (TRAILR4)2 | 2.42 × 101 | 2.11 × 10−3 |
| R3 | TRAILR1 + TRAILR4 ↔ TRAILR1-TRAILR4 | 1.46 × 101 | 1.13 × 10−3 |
| R4 | (TRAILR1)2 + TRAIL ↔ (TRAILR1)2-TRAIL | 1.43 × 10−4 | 4.13 × 10−3 |
| R5 | (TRAILR4)2 + TRAIL ↔ (TRAILR4)2-TRAIL | 7.04 × 10−5 | 4.38 × 10−3 |
| R6 | TRAILR1-TRAILR4 + TRAIL ↔ TRAILR1-TRAILR4-TRAIL | 1.00 × 10−4 | 4.25 × 10−3 |