Table 1.
Cell line characteristics and the status of ACVR1B and SMAD4
|
Cell lines |
Source |
Histology |
ACVR1B |
SMAD4 |
||
|---|---|---|---|---|---|---|
| CN | Expression | CN | Expression | |||
| Sui65 |
Peritoneum |
Tubular |
0 |
- |
0 |
- |
| Sui66 |
Pancreas |
Tubular |
1 |
+ |
2 |
++ |
| Sui67 |
Pancreas |
Tubular |
1 |
- |
1 |
+ |
| Sui68 |
Pancreas |
Ad |
0 |
- |
1 |
+ |
| Sui70 |
Pancreas |
Ad |
2 |
+ |
0 |
- |
| Sui71 |
Liver |
Ad |
1 |
+ |
0 |
- |
| Sui73 |
Pancreas |
Tubular |
2 |
+ |
2 |
+ |
| Sui74 | Pancreas | Tubular | 1 | + | 1 | - |
ACVR1B, activin receptor A, type IB; Tubular, tubular adenocarcinoma; Ad, adenocarcinoma; CN, gene copy number.
Legend: The copy numbers of the ACVR1B gene in the Sui65 and Sui68 cell line was 0, and the copy numbers of the SMAD4 gene in the Sui65, Sui70, and Sui71 cell lines were all 0. ACVR1B mRNA was scarcely expressed in the Sui65 and Sui68 cell lines, and SMAD4 mRNA was also scarcely expressed in the Sui65, Sui70, and Sui71 cell lines. These results were similar to those for the copy number assay.