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PI3K inhibitors induced apoptotic markers in xenografts to a greater extent than in cells grown in culture. Immunoblots against phospho-H2AX (Ser139) and cleaved PARP as a function of treatment with PI3K inhibitors in cells grown in culture A, or in tumor xenografts B, Bottom graphs show the normalized densitometry values of three biological replicates (values are mean ± S.E., n = 3). * p < 0.05 by the Wilcoxon test.
