Skip to main content
. 2014 Apr 1;13(6):1552–1562. doi: 10.1074/mcp.M113.031203

Fig. 5.

Fig. 5.

Comparison of gene-centric, protein-centric, and splice-variant-centric quantitative analysis. The figure presents three examples (EIF4H, ITGB4, and SHROOM3) from the A431 dataset in which discrepancies were observed among gene-centric, protein-centric, and splice-variant-centric analyses. Fold changes are reported for different time points after treatment with gefitinib. The numbers in the parentheses are the number of PSMs used for quantification in each analysis. In gene-centric analysis, all PSMs mapping to that gene were used to calculate the fold change. In protein-centric analysis, PSM grouping was done by the search engine. In splice-variant-centric analysis, only PSMs from SVSPs are used for fold-change calculation. For further details, see the “Results” section.