Table II. p values for significant associations between genetic polymorphisms and glycan structures or traits obtained by different methods. Bold text indicates that the p value reaches genome wide significance (p < 5 × 10−8).
| Glycan Structure Or Trait | Genes in Associated Region | SNP | Association p-Value |
|||||
|---|---|---|---|---|---|---|---|---|
| UPLC-FLR | MALDI-TOF-MS (IgG1) | MALDI-TOF-MS (IgG2&3) | LC-ESI-MS (IgG1) | LC-ESI-MS (IgG2&3) | xCGE-LIF | |||
| FA2BG1a | SMARCB1; DERL3 | rs9620326 | 1.47E-10 | 1.15E-07 | 1.70E-06 | 1.63E-08 | 4.11E-10 | 1.11E-10 |
| 1.54E-04 | 7.46E-06 | |||||||
| FA2G1S1 | ST6GAL1 | rs6764279 | 2.80E-22 | 0.2556 | 4.36E-10 | 1.13E-28 | 1.15E-27 | 1.60E-18 |
| FGS/(FG+FGS) | ST6GAL1 | rs6764279 | 1.14E-20 | 0.0154 | 1.86E-12 | 4.87E-12 | 1.64E-25 | 4.83E-18 |
| FGS/(F+FG+FGS) | ST6GAL1 | rs6764279 | 3.25E-04 | 0.1008 | 1.97E-04 | 1.21E-05 | 1.44E-09 | 3.82E-07 |
| FG1S1/(FG1+FG1S1) | ST6GAL1 | rs6764279 | 1.50E-22 | 0.3941 | 9.60E-21 | 2.51E-33 | 1.31E-40 | 5.61E-22 |
| FG2S1/(FG2+FG2S1+FG2S2) | ST6GAL1 | rs6764279 | 1.54E-36 | 1.26E-11 | 3.49E-23 | 4.67E-26 | 1.37E-32 | 1.71E-37 |
a This glycan structure is measured as two isomers with UPLC-FLR and xCGE-LIF (FA2[6]BG1, with galactose on the 6-arm and FA2[3]BG1, with galactose on the 3-arm), but as only one mass in the MS methods.