Fig. 2.

Schematic representation of the subependymal NPCs niche in the animal hypothalamus. The neurogenic zones are located in the vicinity of the third ventricle at the level of paraventricular, ventromedial, and arcuate nuclei (hypothalamic ventricular zone, HVZ), while tanycytes of the median eminence form the hypothalamic proliferating zone (HPZ). Ciliated and non-ciliated ependymocytes line the third ventricle as well as four types of tanycytes. Various populations of glial cells (fibrous astrocytes, subependymal astrocytes, and oligodendrocyte precursor cells) and neural cells (peptidergic neurons, parenchymal proliferative cells, GnRH-releasing neurons, and doublecortin-expressing immature neurons) are located beneath the ependymal layer forming the NPCs niche. Neuropeptides and other regulatory factors are released from the capillary network