Table 1.

SCID-X1 dogs treated with in vivo–injected foamy virus vector

Animal	Age at injection	Titer (I.U./mL)	VCM volume (mL)	Final dose (I.U.)	Survival (days)
X348	13 d.o.	1.4 × 108	1.4 (×2)	4.0 × 108	139
X349	13 d.o.	1.4 × 108	1.4 (×2)	4.0 × 108	306
R2152	12 d.o.	3 × 108	1.4 (×2)	8.4 × 108	101
R2202	1 d.o.	3 × 108	0.7 (×2)	4.2 × 108	330
R2203	1 d.o.	3 × 108	0.7 (×2)	4.2 × 108	119

Virus was delivered in 2 fractionated doses, 4 hours apart, at the day of life indicated for each dog. The VCM volume is volume per injection, and the total volume received is multiplied by 2 for fractionated injections.

d.o., days old; I.U., infectious units; VCM, vector-conditioned medium.