Table 3.
The genotype distributions and allele frequencies of the studied polymorphisms between patients and controls, and their risk prediction for CD under three genetic models of inheritance
| Polymorphism | CD group (%) | Healthy control (%) | χ 2 | P † | allele | CD group (%) | Healthy control (%) | χ 2 | P ‡ | CD group HWe P b | Healthy control HWe P b | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs2293152 |
GG |
58 (25.2) |
78 (28.7) |
|
|
G |
253(55.0) |
292(53.7) |
|
|
|
|
| CG |
137 (59.6) |
136(50) |
5.16 |
0.08 |
C |
207(45.0) |
252(46.3) |
0.18 |
0.67 |
0.21 |
0.93 |
|
| CC |
35 (15.2) |
58 (21.3) |
|
|
|
|
|
|
|
|
|
|
| OR; 95% CI; P |
Additive model: 094; (0.73,1.23); 0.66 |
Dominant model: 1.19; (0.8,1.77); 0.39 |
Recessive model: 0.66; (0.42,1.05); 0.08 |
|||||||||
| rs4796793 |
CC |
111 (47.8) |
112 (41.2) |
|
|
C |
324 (69.8) |
345 (63.4) |
|
|
|
|
| |
CG |
102 (44.0) |
121 (44.5) |
5.38 |
0.07 |
G |
140(30.2) |
199 (36.6) |
4.61 |
0.03 |
0.51 |
0.50 |
| |
GG |
19 (8.2) |
39 (14.3) |
|
|
|
|
|
|
|
|
|
| OR; 95% CI; P |
Additive model: 075; (0.58,0.98); 0.03 |
Dominant model: 0.76; (0.57,1.09); 0.13 |
Recessive model: 0.53; (0.30,0.95); 0.03 |
|||||||||
| rs744166 |
TT |
106(48) |
98 (36.2) |
|
|
T |
309 (69.9) |
323 (59.6) |
|
|
|
|
| |
CT |
97(43.9) |
127 (46.9) |
11.62 |
0.003 |
C |
133 (30.1) |
219 (40.4) |
11.28 |
0.0008 |
0.52 |
0.66 |
| |
CC |
18 (8.1) |
46 (16.9) |
|
|
|
|
|
|
|
|
|
| OR; 95% CI; P | Additive model: 063; (0.48,0.83); <0.001 | Dominant model: 0.61; (0.43,0.81); 0.008 | Recessive model: 0.43; (0.24,0.77); 0.005 | |||||||||
Abbreviations:HWe Hardy-Weinberg equilibrium. P values were calculated using χ2 test 3 × 2 contingency table (†) for genotype distributions and 2 × 2 contingency table (‡) for allele distributions.OR, 95%CI and P values were calculated by logistic regression analysis.