Table.
Baseline Characteristics
| Overall (n=99) | Low HIR (n=50) | High HIR (n=49) | P Value | |
|---|---|---|---|---|
| Age, mean (SD) | 65 (16) | 66 (19) | 65 (15) | 0.692 |
| Sex (female), n (%) | 50 (51) | 27 (54) | 23 (47) | 0.549 |
| SBP, mean (SD) | 147 (24) | 146 (25) | 148 (22) | 0.797 |
| DBP, mean (SD) | 80 (19) | 78 (19) | 83 (19) | 0.207 |
| Glucose, mean (SD) | 135 (50) | 134 (53) | 135 (46) | 0.952 |
| Hypertension, n (%) | 68 (69) | 37 (74) | 31 (65) | 0.382 |
| Diabetes mellitus, n (%) | 19 (19) | 7 (14) | 12 (25) | 0.206 |
| Hyperlipidemia, n (%) | 50 (51) | 25 (50) | 25 (52) | 0.843 |
| Atrial fibrillation, n (%) | 34 (35) | 16 (32) | 18 (38) | 0.672 |
| History of stroke/TIA, n (%) | 21 (21) | 7 (14) | 14 (29) | 0.086 |
| IV tPA, n (%) | 53 (54) | 24 (48) | 29 (59) | 0.316 |
| NIHSS, median (IQR) | 16 (11–19) | 13 (8–18) | 18 (14–21) | <0.001 |
| dMRI, mL, median (IQR) | 15 (7–32) | 9 (2–15) | 28 (15–52) | <0.001 |
| TMax >6 s, mL, median (IQR) | 80 (47–115) | 63 (41–81) | 112 (80–137) | <0.001 |
| TMax >10 s, mL, median (IQR) | 27 (12–55) | 12 (4–22) | 57 (41–76) | <0.001 |
| FLAIR 5-day infarct volume, mL, median (IQR) | 74 (25–138) | 32 (14–76) | 120 (68–203) | <0.001 |
| HIR, median (IQR) | 0.39 (0.23–0.51) | 0.23 (0.11–0.3) | 0.51 (0.45–0.63) | <0.001 |
| Target mismatch, n (%) | 81 (82) | 46 (92) | 35 (71) | 0.004 |
| Malignant, n (%) | 8 (8) | 0 (0) | 8 (16) | 0.009 |
| Matched, n (%) | 10 (10) | 4 (8) | 6 (12) | |
| Mismatch volume, mL, median (IQR) | 59 (31–85) | 46 (28–67) | 71 (42–94) | 0.011 |
| Time from symptom onset to MRI, h, median (IQR) | 4.5 (2.7–6.2) | 4.6 (4.1–7) | 3.9 (2.6–5.4) | 0.071 |
DBP indicates diastolic blood pressure; dMRI, diffusion-weighted magnetic resonance imaging; FLAIR, fluid attenuated inversion recovery; HIR, hypoperfusion intensity ratio; IQR, interquartile range; IV tPA, intravenous tissue-type plasminogen activator; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure; TIA, transient ischemic attack; and TMax, time when the residue function reaches its maximum.