TABLE I.
Distribution of traits across clusters
| AOE classification | Cluster 1 (n = 300)
|
Cluster 2 (n = 202)
|
Cluster 3 (n = 218)
|
Cluster 4 (n = 225)
|
Cluster 5 (n = 96)
|
|---|---|---|---|---|---|
| LLL | HLL | HHM | MHH | HHH | |
| Asthma history | |||||
|
| |||||
| Age of asthma onset (y) | 3.52 ± 2.63 | 3.09 ± 2.40 | 3.66 ± 2.62 | 2.21 ± 1.89 | 2.27 ± 1.80 |
|
| |||||
| No. of subjects ever hospitalized for asthma (%) | 0 (0) | 0 (0) | 1 (0.46) | 225 (100) | 94 (97.9) |
|
| |||||
| ED visits for asthma (no./100 person-years) | 44.3 | 47.0 | 70.2 | 75.6 | 101 |
|
| |||||
| Atopic features | |||||
|
| |||||
| History of AD (%) | 0 (0) | 202 (100) | 2 (0.1) | 0 (0) | 94 (97.9) |
|
| |||||
| History of hay fever (%) | 61 (20.3) | 132 (65.3) | 191 (87.6) | 119 (52.9) | 54 (56.3) |
|
| |||||
| History of positive skin test responses (%) | 230 (76.7) | 185 (91.6) | 209 (95.9) | 198 (88) | 92 (95.8) |
|
| |||||
| Total serum IgE levels (log10) | 2.37 ± 0.70 | 2.72 ± 0.72 | 2.79 ± 0.58 | 2.64 ± 0.61 | 2.81 ± 0.63 |
|
| |||||
| Spirometry | |||||
|
| |||||
| Prebronchodilator FEV1 (% predicted) | 96.4 ± 12.7 | 97.7 ± 14.8 | 89.7 ± 13.9 | 91.4 ± 13.8 | 92.0 ± 16.1 |
|
| |||||
| Prebronchodilator FEV1/FVC (% predicted) | 81.8 ± 7.68 | 81.5 ± 7.59 | 77.6 ± 8.54 | 77.8 ± 8.24 | 78.6 ± 9.60 |
|
| |||||
| Prebronchodilator peak flow | 276.1 ± 67.3 | 274.3 ± 73.3 | 276.7 ± 69.1 | 276.4 ± 70.8 | 255.6 ± 73.3 |
|
| |||||
| Airway responsiveness | |||||
|
| |||||
| Methacholine PC20 (natural log) | 0.71 ± 1.03 | 0.14 ± 1.11 | −0.54 ± 1.00 | 0.038 ± 1.14 | −0.23 ± 1.17 |
|
| |||||
| FEV1 bronchodilator response (L) | 0.077 ± 0.07 | 0.097 ± 0.08 | 0.12 ± 0.11 | 0.12 ± 0.11 | 0.16 ± 0.14 |
|
| |||||
| Anthropomorphic features | |||||
|
| |||||
| BMI (kg/m2) | 18.1 ± 3.46 | 18.6 ± 3.83 | 18.5 ± 3.66 | 17.8 ± 3.19 | 17.6 ± 3.38 |
|
| |||||
| Waist/hip ratio | 0.882 ± 0.06 | 0.885 ± 0.07 | 0.881 ± 0.06 | 0.874 ± 0.05 | 0.877 ± 0.07 |
|
| |||||
| Peripheral blood counts | |||||
|
| |||||
| Eosinophils (log10) | 2.35 ± 0.55 | 2.54 ± 0.53 | 2.57 ± 0.52 | 2.50 ± 0.49 | 2.71 ± 0.41 |
|
| |||||
| Lymphocytes (%) | 42.1 ± 11.5 | 40.9 ± 9.82 | 41.1 ± 10.9 | 41.7 ± 10.5 | 40.8 ± 9.78 |
|
| |||||
| Neutrophils (%) | 45.5 ± 12.2 | 44.5 ± 11.0 | 44.6 ± 11.5 | 44.7 ± 11.5 | 43.1 ± 11.0 |