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. Author manuscript; available in PMC: 2014 Jun 6.
Published in final edited form as: Neuron. 2013 May 22;78(4):623–630. doi: 10.1016/j.neuron.2013.03.021

Figure 4. Effect of Monoamine Oxidase-B (MAO-B) Inhibitors on Cocaine-Induced Locomotor Sensitization of Mice.

Figure 4

(A) Analysis of nitrosylation of GAPDH in primary cortical neuronal cells treated with the MAO-B inhibitors deprenyl, rasagiline, lazabemide, or pargyline. (B) Treatment with deprenyl, rasagiline, lazabemide, or pargyline has no effect on cell survival of primary cortical neurons. (C–F) Analysis of locomotor sensitization by open-field test upon treatment with deprenyl (C), rasagiline (D), pargyline (E), or lazabemide (F) with or without cocaine. #p < 0.05, n= 10–12, two-way ANOVA, mean ± SEM. (G and H) Total beam breaks were measured in mice treated with cocaine alone or with cocaine anddeprenyl (G), rasagiline, lazabemide or pargyline (H). *p < 0.01, n = 10–12, one-way ANOVA, mean ± SEM.