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. Author manuscript; available in PMC: 2014 Jun 6.
Published in final edited form as: Cancer Biol Ther. 2010 Jun 25;9(11):928–935. doi: 10.4161/cbt.9.11.11873

Figure 2. ASA, FK228 and the combination of drugs induce a G0/G1 cell cycle arrest and increase sub-diploid DNA content in OVCAR-3 ovarian cancer cells.

Figure 2

Cells were treated for 48 h with ASA (1 mM), FK228 (4, 8 and 16 nM) or the combination. Flow cytometry assays were performed to determine the percentage of cells in each phase of the cell cycle and the percentage of cells with sub-diploid DNA content as a measure of apoptosis. Experiments were performed in triplicate and all data are shown as mean ± SE. Asterisks indicate significance (p ≤ 0.05) using the paired Student’s t-test.