Table 1.
Protein hits that are differentially expressed in SUR2KO-IR and WT-IR hearts
| Identified hits | Gene name | P-Value | Fold of change (KO/WT) |
|---|---|---|---|
| Mitochondrial peptide methionine sulfoxide reductase |
Msra |
0.0624981 |
0.19 |
| 1,4-alpha-glucan-branching enzyme |
Gbe1 |
0.0221348 |
0.3 |
| 40S ribosomal protein S3 |
Rps3 |
0.0570084 |
0.32 |
| Estradiol 17-beta-dehydrogenase 10 |
Hsd17b10 |
0.007576 |
0.48 |
| Estradiol 17-beta-dehydrogenase 8 |
Hsd17b8 |
0.0257942 |
0.52 |
| Dynamin-like 120 kDa protein |
Opa1 |
0.0133927 |
0.59 |
| Mitochondrial 2-oxoglutarate/malate carrier protein |
Slc25a11 |
0.0229143 |
0.63 |
| ATP synthase subunit gamma, mitochondrial |
Atp5c1 |
0.0742584 |
0.66 |
| ATP synthase subunit alpha, mitochondrial |
Atp5a1 |
0.0866386 |
0.77 |
| Cytochrome c oxidase subunit 5A, mitochondrial |
Cox5a |
0.0371111 |
0.79 |
| Prohibitin-2 |
Phb2 |
0.0500592 |
1.3 |
| Propionyl-CoA carboxylase beta chain, mitochondrial |
Pccb |
0.0813775 |
1.3 |
| Heat shock protein HSP 90-beta |
HSP90AB1 |
0.0215257 |
1.3 |
| Cytochrome b-c1 complex subunit 1, mitochondrial |
Uqcrc1 |
0.0602446 |
1.5 |
| CDGSH iron-sulfur domain-containing protein 1 |
Cisd1 |
0.0446392 |
1.6 |
| T-complex protein 1 subunit beta |
Cct2 |
0.0880331 |
1.6 |
| Basement membrane-specific heparan sulfate proteo-glycan core protein |
Hspg2 |
0.0499444 |
1.6 |
| Pyruvate dehydrogenase protein X component, mitochondrial |
Pdhx |
0.0121642 |
1.7 |
| Catenin alpha-1 |
Ctnna1 |
0.0364573 |
1.7 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 |
Ndufa13 |
0.0596356 |
1.7 |
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
Sdhb |
0.0079267 |
1.7 |
| Electron transfer flavoprotein subunit beta |
Etfb |
0.0489129 |
1.8 |
| ATP synthase subunit d, mitochondrial |
Atp5h |
0.0923448 |
1.8 |
| Hemoglobin subunit beta-1 |
Hbb-b1 |
0.032562 |
1.8 |
| Cytochrome b-c1 complex subunit 8 |
Uqcrq |
0.0703449 |
1.9 |
| Ferritin light chain 1 |
Ftl1 |
0.0305524 |
1.9 |
| Cofilin-1 |
Cfl1 |
0.0619513 |
1.9 |
| Acyl-CoA dehydrogenase family member 10 |
Acad10 |
0.0765324 |
2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 |
Ndufa7 |
0.089645 |
2 |
| Adenosylhomocysteinase |
Ahcy |
0.0612594 |
2.1 |
| Lipoprotein lipase |
LPL |
0.0690628 |
2.3 |
| Talin-1 |
Tln1 |
0.0040294 |
2.3 |
| Laminin subunit gamma-1 |
Lamc1 |
0.0178447 |
2.4 |
| Junction plakoglobin |
Jup |
0.0020557 |
2.6 |
| AFG3-like protein 2 |
Afg3l2 |
0.0210335 |
2.9 |
| Glutathione S-transferase P 1 |
Gstp1 |
0.0086305 |
3 |
| NSFL1 cofactor p47 |
Nsfl1c |
0.0965357 |
3.3 |
| Ubiquitin carboxyl-terminal hydrolase 14 |
Usp14 |
0.0142878 |
4.4 |
| Vesicle-associated membrane protein-associated protein B |
Vapb |
0.0669842 |
4.9 |
| Adenylyl cyclase-associated protein 1 |
Cap1 |
0.034702 |
5.6 |
| Glutaredoxin-1 | Glrx | 0.0590062 | Only detected in KO |
Summary data of semi-quantitative proteomic comparisons using SUR2KO-IR and WT-IR hearts. P-values were calculated using a pair-wise t-test based on three replicates from each group of mice. p < 0.1 was considered statistically significant. The fold of expression change is shown as a ratio of KO/WT. The cut-off is set at 1.3-fold of difference.